Dr. Sadati considers an ideal graft tissue is the one that is readily available, well accepted by the body, safe to obtain for grafting, and not provide risk of rejection or disease transmission. Autologous fat grafts (patients own fat) have proven to meet each and all of these criteria.
However, there are still some surgeons and patients reporting disappointment with their fat transfer survival, indicating it is unpredictable or only temporary. According to Dr. Sadati’s research long lasting results with fat grafting depends on careful tissue handling and preparation for transfer and importantly addition of Platelet Rich Plasma (PRP). He and his colleagues have participated in several clinical studies on small and large volume fat transfer with PRP, and have shown excellent outcomes and long lasting results. Addition of PRP has shown to increase the retention of the transplanted fat cells, as well as the rate of “take” (meaning the acceptance of the new cells in the desired sites, where they may permanently survive). Further, gentle tissue gathering and handling is considered essential for success in insuring that the fat cells are not damaged during harvesting process. As opposed to use of high vacuum pump powered liposuction, he recommends a low-pressure closed-syringe technique to harvest the fat cells, resulting in a minimal amount of damage to the fat cells.
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